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In atrophying muscles, there is activation of the Forkhead box O transcription factor family (FOXO), as well as NF-B, which can be activated by TNF-, soluble TNF-like weak inducer of apoptosis (TWEAK), or IL-1 [15, 16]

Unlike IGF-1 LR3, which has a long half-life (2030 hours) and systemic activity, IGF-DES has a significantly shorter half-life (2030 minutes) but an intense localized effect

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