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At the imaging level, metabolic imaging modalities such as positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and emerging techniques like magnetic resonance spectroscopic imaging (MRSI) are being employed for non-invasive assessment of tumor metabolic activity and mitochondrial function [141, 142]

doi: 10.1016/j.biocel.2016.07.017 41

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Modulates Gene Expression Influences thousands of genes tied to cellular repair and growth

This structural damage causes further mitochondrial failure and even more ROS leakage, creating a continuous "doom loop" of profound energy depletion, systemic inflammation, and the hallmark symptom of post-exertional malaise (PEM)