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no establecida en humanos Farmacocintica : Potencialmente variable debido a diferencias en grosor cutneo, flujo sanguneo, hidratacin y temperatura Ventajas tericas : No invasiva, potencialmente mejor adherencia, evita metabolismo de primer paso heptico Desafos : Tamao molecular grande, degradacin enzimtica cutnea, irritacin local, rea de aplicacin requerida potencialmente grande Desde una perspectiva de seguridad del paciente, las formulaciones actualmente aprobadas ofrecen control de dosis preciso y resultados clnicos predecibles
The formal decision was announced in 1987, and a complex eviction process involving HK$2.7 billion (US$350 million) in compensation was completed in 1992
The Prohibited List is updated annually and comes into effect on 1 January every year, and any changes to the Prohibited List are made public every year in early October for changes applicable to the upcoming year
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