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Two unrelated Chinese patients with hyperinsulinism/hyperammonemia (HI/HA) syndrome due to mutations in glutamate dehydrogenase gene., J Pediatr Endocrinol Metab 2010;23:733-738

Certain vitamins add to the effect

SIRT1 targets both histone and non-histone substrates, including histones (e.g., H3K9, H4K16 31 ) and transcriptional regulators such as p53, 32 FOXO1/3a, 33 PGC-1, 34 LKB1, 35 and NF-B p65, 36 thereby contributing to epigenetic regulation and broader cellular functions

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