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In her primary care practice, Dr

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Nasal sprays formulated outside the isotonic range (270330 mOsm/kg) can cause irritation and impair the nasal mucociliary clearance apparatus the cilia-driven transport system that moves mucus, particles, and pathogens from the nasal cavity toward the nasopharynx

Because both come from the same vial, only the entered target changes the concentration stays fixed until you mix a new vial