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A U-shaped dose-response and time-of-infusion curve has been documented an important design consideration for DSIP research, as both sub-threshold and supra-threshold doses may produce attenuated effects relative to the optimal dose range

Metformin also regulates apoptosis by downregulating Bcl-2 and Bcl-xL expression and upregulating Bax and Cytochrome expression (43)

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