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The authors of the meta-analysis examined if maternal serum homocysteine levels, folic acid supplementation, or gestational age could explain the variation in the results, but none significantly explained the difference between studies

Pale or jaundiced skin: Reduced red blood cell production can cause a pale appearance or yellowish tinge to the skin

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Pataer A, Shao R, Correa AM, Behrens C, Roth JA, Vaporciyan AA, Wistuba II, Swisher SG

* These therapies are not FDA approved for the treatment, cure, or prevention of any disease

He noted that the three pillars of an FDA finding of safe and effective include demonstrating clinical efficacy, validating the manufacturing process and completing the required toxicology studies