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It promotes formation of new blood vessels, reduces oxidative stress markers, and modulates the nitric oxide system (Hsieh et al., 2017)

Glp1r / mice were kindly provided by D

531 Both SIRT1 and SIRT3 exert their function through PGC-1, which acts as a modifier in HD and ALS patients and other models

Nat Commun 11 , 3978 (2020)

Excess weight promotes the development of a wide range of pathologies (insulin resistance, hypertension, chronic inflammation, dyslipidemia), which increase the risk of complications such as type 2 diabetes, cardiovascular disease, hepatic steatosis, several types of cancer and reduce life expectancy

doi:10.1016/j.fertnstert.2015.09.024