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For these patients, starting at 0.1 mg and titrating upward in smaller increments (0.1 to 0.15 to 0.2 to 0.25 mg) over 8 to 12 weeks may allow the GI tract to adapt without the abrupt disruption

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Gastrointestinal tolerance : Nausea and reduced appetite during the first weeks may contribute to early caloric restriction, but significant side effects can also affect adherence

If the reddening does not disappear after 24 hours do not use the product

FDA green-lights tirzepatide, marketed as Zepbound, for chronic weight management