Clinical trials show variable lipid effects across GLP-1 receptor agonists, with differences generally modest and correlating with weight loss achieved
GLP-1 receptor agonists and the risk of thyroid cancer
The clinical pipeline represents diverse approaches to differentiation, including alternative receptor combinations, novel delivery mechanisms, and improved tolerability profiles
Currently available options in the UK include: Orlistat a licensed oral medication available on prescription or over the counter Semaglutide 2.4 mg (Wegovy) a once-weekly injection approved by NICE (TA875) for eligible patients within a specialist weight management service Tirzepatide (Mounjaro) MHRA-authorised for type 2 diabetes
Express Scripts also announced updates recently to another of its GLP-1 solutions, EncircleRx, which has more than 9 million enrolled patients and has saved health plans $200 million since 2024
Piper may work for patients who prioritize speed and low cost above all else, but most patients would be better served by similarly priced competitors with stronger track records
