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Management of Immunotherapy-Related Toxicities, Version 1.2019

Model and physiological GSSR substrates are, for example, l-cysteine-glutathione disulfide (GSSCys) 9,10,11,12,13,14,15 , coenzyme A-glutathione disulfide 3,16 , as well as S -glutathionylated serum albumin 9,11,17,18,19,20 , sirtuin 21 , sulfiredoxin 22 , and peroxiredoxins 23,24,25,26,27,28,29

L., & Magrina, J

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Foxo transcription factors in T cell biology and tumor immunity

In some embodiments, a concentration of the otoprotectant, wherein the otoprotectant is an antioxidant or an anti-apoptotic agent is in a range of about 0.1 M to about 100 M, about 1 M to about 100 M, about 10 M to about 100 M, or about 50 M to about 100 M