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The largest study, a 68-week double-blind trial of nearly 2,000 obese adults who did not have diabetes, found that people who took 2.4 mg of semaglutide weekly in addition to participating in a diet and exercise program lost significantly more weight than those who made the same lifestyle changes but were given placebo injections

like Spain [22], and the US [23]

However, an early deterioration in retinopathy, such as with soft exudates, microaneurysms and haemorrhage, can occur in the first six months after rapid correction of significant hyperglycaemia

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Early data further suggest Retatrutide might offer neuroprotective benefits, possibly due to improved metabolic health and reduced systemic inflammation, pointing to a broader therapeutic potential in preserving cognitive function and preventing dementia