Indeed, G6PD-deficient monocytes exhibit decreased inflammasome responsiveness to LPS, including poor induction of pro-interleukin-1 (IL-1), which has been linked to insufficient NADPH oxidase production of ROS and impaired intracellular bacterial killing (18)
Bizzarri, M., Fuso, A., Dinicola, S., Cucina, A
(2011) Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide, Biochim Biophys Acta
As you'll be using a subcutaneous vaccine, it's best to administer it on the loose skin found behind the shoulder blade
doi: 10.1016/j.ntt.2012.09.002
In a 48-week phase II clinical trial conducted on patients with type 2 diabetes and obesity, treatment with a dose of 10 mg/kg of bimagrumab resulted in a significant reduction in fat mass by 20.5% (compared to 0.5% in the placebo group), while lean body mass increased by 3.6% (as opposed to a decrease of 0.8% in the placebo group), leading to an overall body weight reduction of -6.5%, which was substantially better than the -0.8% observed in the placebo group