The implications for people who experience both obesity and chronic migraines are significant, and researchers in brain function optimization are paying close attention
The absurd thing is that patients began to lose a lot of weight
Fat Reduction
Dale AM, Fischl B, Sereno MI
Because amylin signalling is closely linked to meal termination, satiation, and brainstemhypothalamic regulation of food intake, amylinGLP-1 co-agonism may reshape eating experience through mechanisms that partly overlap with, but are not identical to, classical GLP-1R agonism
- Mechanism: Orforglipron stimulates the GLP-1 receptor, increasing insulin secretion, reducing glucagon, slowing stomach emptying, and affecting appetite centers in the brain