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This is because, despite the diagnostic accuracy of liver biopsy, studies reporting liver biopsy as a diagnostic tool have been limited due to its invasive nature and high cost

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Also, the adverse cardiovascular safety in clinical trials before 2008 was evaluated based on populations that were not necessarily at high risk of cardiovascular disease and the follow-up duration was relatively short (usually less than 12 months)

cGAS-STING pathway: DAMP-mediated activation of type I interferon response and the key role of DNA sensors cGAS functions as a DNA sensor

10.1016/j.berh.2011.01.012 68 GambariL.CellamareA.D'AlessandroM.GrigoloB.GualandiC.VelinoC.et al (2025)