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The acute toxicology in animal models appears relatively benign, but animal toxicology does not establish human safety across chronic exposure

Homeostatic maintenance of the lymphatic vasculature

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Kaufmann, E

Bottom: volcano plot showing relative fold change (log 2 ) in whole cell metabolite abundance versus log 10 (P value) from ER-tag HEK293T cells treated with thapsigargin compared to untreated