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In the first step, pattern recognition receptors such as Toll-like receptors detect MSU crystals and activate the nuclear factor kappa B (NF-B) signaling pathway ( 5 Inflammation amplification and cell recruitment phase: the dominant role of neutrophils 5.1 Neutrophil infiltration and activation During the early phase of tophus development, neutrophil recruitment and activation form the central processes that initiate and amplify the inflammatory response
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Apr 20 2007;5:15
Curcumin analogue ai-44 alleviates msu-induced gouty arthritis in mice via inhibiting cathepsin b-mediated nlrp3 inflammasome activation
10.2165/00002512-200320130-00001 79 LephartE
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