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It activates GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors

27 Orforglipron can be taken at any time of day without restrictions on food or water intake and possesses significantly higher oral bioavailabilityestimated at 21-28% in primates, compared to less than 1% for peptide oral formulations

doi: 10.3390/jpm13050830 45 WilliamsDLBaskinDGSchwartzMW

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10.1016/bs.apha.2025.01.011 205 QuanY.ZhangH.WangM.PingH