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Research Limitations and Contraindications Certain research models present limitations that must be considered

10.1016/j.archger.2023.105081 96 Fiatarone SinghM

The modulation of metabolomics and antioxidant stress is involved in the effect of nitazoxanide against influenza A virus in vitro

Our team has identified a few key areas that are likely culprits

The intermediates from de novo lipogenesis in the liver will disrupt mitochondrial function and produce ROS, and then cause endoplasmic reticulum (ER) stress, ultimately leading to inflammation, and the broken cells releasing cytokines will cause more cell death ( The excess free fatty acids (FFAs) and de novo lipogenesis would break the homeostasis of lipid metabolism

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