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The observed beneficial effects of GLP-1 RAs likely translate into real-world settings, given that discontinuation rates may be lower for GLP-1 RAs than for other antidiabetic medications ( Additional investigations should focus on populations with optimal cardiovascular health in order to clarify the efficacy of GLP-1 RAs in primary prevention

Compounded semaglutide and tirzepatide are not FDA-approved , and theyre appropriate only in specific situations, generally when a patient has a documented medical need that a commercially available product cant meet

This may further help limit excessive glucose production by the liver

Garvey WT, Batterham RL, Bhatta M, Buscemi S, Christensen LN, Frias JP, et al

However, individual responses can vary, with some individuals experiencing changes sooner and others taking longer to see results