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Compared with classical oral-hypoglycemic drugs, biguanides, thiazolidinediones, sulfonylureas, and alpha glucosidase inhibitors, patients receiving DPP-4i treatment have a lower incidence of hypoglycemic events and gain less weight

It has been demonstrated that ligand-activated GLP- 1 receptor interacts with the Gas subunit and activates adenylate cyclase to generate cAMP

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Pre-exposure assessment of those exposed to chemicals of immunomodulating potential should be considered in order to document any pre-existing features of connective tissue diseases