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Vitamin B12 Medicine Interactions Chloramphenicol: bacteriostatic antibiotic can interfere with red blood cell response to supplemental Vit B12 Proton pump inhibitors: omeprazole and lansoprazole, etc., slow gastric acid release and may interfere with VIt B12 absorption from food H2-receptor antagonists: cimetidine, famotidine and ranitidine slow the release of hydrochloric acid into the stomach and interfere with Vitamin B12 absorption from food Metformin: might reduce absorption of Vitamin B12 due to altered intestinal motility, increased bacterial overgrowth, etc

Yes, in most cases, vitamin injections can be combined with oral supplements

Formulation matters too

This came to be known as the Myers' cocktail

The role of vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review

Many people make the mistake of injecting B12 too quickly, which can cause discomfort, bruising, and reduced absorption