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Expansile dermal nests with diffuse cytologic atypia, lack of maturation with depth, significant pagetoid spread of intraepidermal melanocytes, effacement of the epidermis, conspicuous mitoses, and asymmetry should all prompt concern for melanoma
Experimental work has focused on receptor pharmacology, cyclic AMP linked signaling, food intake and energy expenditure pathways, hepatic lipid handling, inflammatory markers, and cross-tissue metabolic communication in animal and biochemical models
10.1016/j.biopha.2020.110524 51 LiY.RanC.WeiK.XieY.XieM.ZhouW.et al (2021a)
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