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Biotechniques 38 , 360366 (2005)

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The menstrual changes are downstream effects of metabolic changes (insulin sensitivity, weight loss), not direct hormonal interference

Furthermore, urinary metabolomics has unveiled shared metabolic pathways and biomarkers between OA and other conditions, such as perturbation in glutamine metabolism, aiding in the enhanced comprehension of OA's pathological mechanisms and offering potential targets for the development of novel therapeutic strategies [91]