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In line with this observation, 2-hydroxybutyrate is increasingly recognized as a biomarker of metabolic disturbances, particularly in insulin resistance and glucose intolerance 27

It contains the coenzyme forms of vitamin B2, B6, folic acid and B12, supplemented by zinc, trimethylglycine and L-serine

Neurochem Res 15:597601 Ricciolini R, Scalibastri M, Kelleher JK, Carminati P, Calvani M, Arduini A (1998) Role of acetyl-l-carnitine in rat brain lipogenesis: implications for polyunsaturated fatty acid biosynthesis

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Accordingly, researchers should evaluate claims or statements regarding GHK-Cus safety with due caution

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