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However, some mushrooms, such as maitake (a.k.a

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The development of DR is complex, and it involves increased production of free radicals, the stimulation of AMP-activated protein kinase/mammalian target of rapamycin signaling pathways, the activation of the renin-angiotensin system, engagement of TGF-/Smad signaling, the kinin system involving kinin-releasing enzymes, the accumulation of AGEs and various inflammatory agents such as VEGF (136-138)

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2.4 Synthesis of SNCDs In our previous study [20], citric acid and urea precursors were applied as a carbon and amine source, respectively