Sorafenib causes the production of P62, which inhibits NRF2 degradation and promotes the inactivation of KEAP1, followed by the activation of heme oxygenase-1 (HO-1), quinone oxidoreductase-1, and ferritin heavy chain-1, which enhances NRF2 nuclear localization
Knobs-into-holes engineering of antibody CH3 domains for heavy chain heterodimerization
Mayr, F
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This observation confirms that the corresponding increase in PI intensity is due to apoptotic processes ( Supplementary Figure S2 )