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[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Turner JD, Rotwein P, Novakofski J, Bechtel PJ

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Activation of FXR stabilizes the nuclear co-repressor (NcoR) at the NF-B response element on the IL-1 promoter, while decreasing the expression of TNF-, IL-1, IL-2, IL-6 and IFN- mRNA, thereby reducing the extent of inflammation (Vavassori et al., 2009)

This specificity is important: the metabolic effects described in this article are tied to these olive-derived compounds specifically, not to polyphenols as a broad category

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It also exhibits analgesic and anti-inflammatory properties, accelerating the healing of sprains, tears, and tissue damage by increasing blood flow to injured areas