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A 2.6% reduction in hip bone mineral density and a 2.1% reduction at the lumbar spine in 52 weeks (Hansen et al., 2024), combined with up to 10.9% lean mass loss over 72 weeks (Look et al., 2025), means that patients on GLP-1 therapy need a comprehensive musculoskeletal protection plan from day one
10.1007/s13300-013-0040-0 27 DayJ
Romero-Gomez M, Lawitz E, Shankar RR, Chaudhri E, Liu J, Lam RLH, et al
Biomarkers such as fasting glucose, HbA1c, lipid panel, and blood pressure inform this assessment
In most but not all studies, a small increase in white blood cell count (approximately 200 cells/microL difference in WBC vs
doi: 10.3390/ijms22126297 143 LarsenSRablRHansenCNMadsbadSHelgeJWDelaF
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