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When fetal fibroblasts were treated with Epitalon over multiple passages, they were able to bypass the Hayflick limit, dividing beyond 44 passages, compared to just 34 in untreated controls [26]

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These phosphorylated tyrosines serve as docking sites for adaptor proteins including insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2), and Shc, which are recruited to the activated receptor and themselves become phosphorylated, initiating multiple downstream signaling cascades

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We find that tig-2 , a ligand in TGF- signalling, activates downstream gonadal longevity pathways (e.g., DA signalling) from DTC (Fig