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The similarity between the unadjusted and adjusted estimates suggested that the single interim analysis had little influence on the final effect size and the reported treatment effect was unlikely influenced by type I error associated with the group sequential design

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Abbott, Dexcom, Inc., Eli Lilly and Company, diaTribe, Insulet Corporation, Medtronic, Roche Diabetes Care, Tandem Diabetes Care, Inc., Ypsomed AG

somerae ZNN-1 significantly increased the crude protein content in muscle, promoted glucose uptake and utilization in muscle tissue, and activated the phosphorylation of S6K/S6 in muscle tissue