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This series helps maintain muscle in a supportive, lower-intensity format that pairs perfectly with higher-effort days or recovery days in John Peels program

NCCIH notes that while individual study findings are promising, evidence quality varies and more rigorous human trials are needed before definitive conclusions can be drawn

PPAR/ activation induces enteroendocrine L cell GLP-1 production

Last reviewed: May 14, 2026 Last updated: May 14, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Importantly, while RCTs consistently demonstrate robust short-term glycemic improvements, real-world data suggest that long-term treatment continuity remains a major challenge

The FDA currently classifies GLP-1 receptor agonists as class C for use in pregnancy, and these medications are not recommended during pregnancy