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GLP-1 is a naturally occurring incretin hormone produced by the gut and brain in response to food intake

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Aescin is the primary bioactive molecule in horse chestnut seeds, with a chemical structure closely related to triterpene glycosides 31

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in Cell Metabolism note that SIRT1 activation improves mitochondrial efficiency and promotes a shift toward lipid utilization for energy, which can be especially beneficial in endurance and fat-loss settings (Price et al., Cell Metabolism )