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Biol Psychiatry (2012) 71:95661.10.1016/j.biopsych.2012.01.014 73 GhanizadehAMoghimi-SaraniE

Am J Physiol 276(3):G751-760

Long exposure to high glucose concentration impairs the responsive expression of g-glutamylcysteine synthetase by interleukin-1b and tumor necrosis factor-a in mouse endothelial cells

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Taken together, these findings suggest that IGF-1-mediated regulation of protein metabolism in humans cannot be excluded as a possible mechanism, although LC supplementation may affect muscle protein balance in people with low circulating IGF-1 level