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Diabetes, Obesity and Metabolism 19.4 (2021): 524536

Metformin can help with weight loss in PCOS patients by improving insulin sensitivity, but results are dose-dependent and won't work for everyone, especially those with advanced insulin resistance

274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

The texture was also very grainy