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Aminoglycosides (e.g., gentamicin, amikacin, kanamycin, tobramycin) chelate iron in cochlear tissues, generating ROS that leads to oxidative stress, mitochondrial dysfunction, and programmed cell death

is supported by the CAS project (CAS-WX2022GC-0104)

Deficiencies in these vitamins can lead to significant neurological and psychiatric conditions, including Wernicke Korsakoff syndrome, Parkinsons disease, and various mental illnesses

10.1074/jbc.m310329200 9 BattagliaA.PakK.BrorsD.BodmerD.FrangosJ

A review of practical issues on the use of glucagon-like peptide-1 receptor agonists for the management of type 2 diabetes

Targeting the incretin/glucagon system with triagonists An even more advanced step towards the generation of an effective anti-obesity pharmacotherapy is the report of a single peptide capable of simultaneously activating the receptors for glucagon, GLP-1, and GIP by using a highly effective, balanced triagonist structure [25]