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Arrestin 2 could regulate post-endocytic sorting of MOR upon DAMGO exposure but not morphine by enabling receptor ubiquitination, as described for different GPCRs (Marchese and Trejo, 2013), but also dephosphorylation on the S375 (Groer et al., 2011)

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doi: 10.1016/j.chom.2017.04.007 132 AuritiCDe RoseDUSantisiAMartiniLPiersigilliFBersaniIet al