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Schreckenberg, D., Griefahn, B
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Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB
We and others further showed a similar effect in mice with Vgat-Cre- mediated deletion of Gipr in gamma-aminobutyric acid (GABAergic) neurons 14,19
Understanding this distinction matters because more potent does not automatically mean more effective for a given patient
This effect often results in weight loss , which is particularly beneficial for many individuals with type 2 diabetes who are overweight or obese
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