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It can, with deliberate work
That being said, its worth noting that GLP-1s may actually be beneficial for IBD patients who are stable, since weight loss can lessen inflammation, which can worsen symptoms of these conditions, Holly Lofton, MD, clinical associate professor of medicine and director of the Weight Management Program at NYU Langone Health, tells SELF
Review Article Abstract Introduction Retatrutide for Treatment of Obesity Retatrutide for Treatment of Type 2 Diabetes Effects of Retatrutide on Cardiovascular Risk Factors Safety of Retatrutide Effect of Retatrutide on Heart Rate Advantages of Retatrutide Limitations of Retatrutide Conclusions and Current Needs References Limitations of Retatrutide The main limitation of retatrutide is the high frequency rates of discontinuation due to adverse effects reaching 17% with the highest doses
Specifically, 45.3% of participants on that arm achieved at least 30% weight loss
A notable new side effect was dysesthesia (skin tingling or sensitivity), reported in about 21% of patients on the highest dose, though generally mild
