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NIR-driven MNMs are often designed as Janus particles, with an asymmetric volume that allows light-absorbing materials to generate a temperature gradient upon exposure to NIR light, driving propulsion [87, 133] ( Fig

They may be prescribed when a patients specific needs cannot be met by a commercially available drug, such as due to allergies to inactive ingredients in branded products or during drug shortages

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Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration