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Biology of Incretins: GLP-1 and GIP

3.3 Weight management and body composition optimization: foundational effect for reproductive benefit Across the diverse landscape of evidence involving various comparators and time windows, weight loss and improvements in body composition emerge as the most consistent and clinically interpretable benefit findings of GLP-1RAs in PCOS, particularly within obesity- and IR-dominant phenotypes

J Clin Med 2022;12:145.ArticlePubMedPMC 50

Perez-Riverol, Y

In one prospective study, greater than 10% weight loss led to regression in liver fibrosis with greater than 5% weight loss reducing hepatic steatosis