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Soluble A oligomers inhibited EAAC1-mediated cysteine uptake and decreased intracellular GSH levels in vitro , even though mRNA expression of EAAC1 was reactively increased by treatment with soluble A oligomers [111]
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Generally, a multidisciplinary team conducts FIH trials, including a clinical pharmacologist, a safety physician, a formulation scientist, a clinical development scientist, a clinical operation specialist, a toxicologist, and a regulatory affair specialist
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