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10.1016/j.fct.2020.111282 44 ReitmanS.FrankelS

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After GPx consumes part of the initial H 2 O 2 substrate, the remaining H 2 O 2 interacts with ferrous ions (Fe 2+ ), proceeding through a classic Fenton-type redox reaction that oxidizes Fe 2+ ions to ferric ions (Fe + )

Several zDHHCs, however, contain PDZ-binding motifs, SH3 domains or ankyrin-repeats outside the catalytic DHHC core that have been implicated in enzyme-substrate interactions 11