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HIV-associated lipodystrophy, linked to antiretroviral therapy, presents with variable lipoatrophy and central adiposity, often sharing similar metabolic derangements [150, 151]
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In the anabolic methionine cycle, niacin, in the form of NAD, is a necessary co-factor for the enzymes dihydrofolate reductase in the folate/tetrahydrobiopterin cycle and S-adenosylhomocysteine hydrolase (1)
External References Mller, T
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Interestingly, supplementation with folate has been found to be about one-third as effective as metformin in reducing insulin resistance and even preventing type 2 diabetes, suggesting it has blood sugar regulating properties
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