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These mediators directly participate in pathogen clearance and activate the expression of pro-inflammatory factors, creating a positive feedback loop with pro-inflammatory cytokines ( IL-15 , IL-10 , TNF- , CASP3 , and CASP9 ( Aquaculture is increasingly becoming a vital source of high-quality protein

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By integrating advances in neuroscience, pharmacology, and molecular medicine, this review emphasizes the promise of Nrf2 as a unifying therapeutic target across diverse CNS pathologies

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Thus, it demonstrates efficient clearance and limited systemic accumulation