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For example, in HEK 293A cells that exogenously express CB 1 receptors, and in a Huntingtons Disease model striatal cell line (ST Hdh Q7/Q7 ), application of CBD induced noncompetitive negative allosteric modulation of CB 1 receptors with CB 1 agonists (Laprairie et al

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Add to this that many patients on GLP-1s already experience mild nausea, vomiting, or diarrhea, and the risk of dehydration climbs quickly when temperatures rise