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Additionally, elesclomol enhanced the cytotoxicity of TH588, a microtubule-modulating agent that induces cell cycle arrest, which relies on endogenous ROS levels [66]
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Future directions Scientists are continually refining and developing new animal models that better recapitulate the complexity of AD, including the genetic and environmental factors contributing to the diseases heterogeneity
Boulos LJ, Ben Hamida S, Bailly J, Maitra M, Ehrlich AT, Gavriaux-Ruff C, et al
Infect Immun (2014) 82(10):41829
Br J Clin Pharmacol 34:7981 Mitchell SJ, Hilmer SN, Murnion BP, Matthews S (2011) Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty
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