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the patient previously failed or was intolerant of the step agent

J Appl Physiol, 1999

Digestive problems: Some allergic reactions cause stomach pain, nausea, vomiting, or diarrhea

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Table of Contents What Is a Calorie Deficit and How Does It Affect the Body How Long a Calorie Deficit Is Generally Safe to Maintain Signs That a Prolonged Calorie Deficit May Be Harming Your Health Risks of Staying in a Calorie Deficit for Too Long NHS and NICE Guidance on Safe and Sustainable Weight Loss When to Speak to a GP or Registered Dietitian Scientific References Frequently Asked Questions What Is a Calorie Deficit and How Does It Affect the Body A calorie deficit occurs when calorie intake falls below total daily energy expenditure, prompting the body to use stored glycogen then fat for energy, while also triggering metabolic adaptations including a reduced basal metabolic rate and increased hunger hormones

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