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Moreover, significant progress has been made in biological therapies, particularly engineered cytokine modulators, macrophage-reprogramming strategies, and extracellular vesicle-based treatments derived from MSCs, all of which have demonstrated anti-inflammatory, chondroprotective, and immunomodulatory effects (Cotter et al., 2020

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They searched the PubMed and Google scholar databases, combining the terms dual agonist OR triple agonist OR GIP/GLP-1 OR [glucagon-like peptide 1] PLUS [glucose dependent inhibitory peptide] OR glucagon/GLP-1 OR dual incretins

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