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Morley JE, Argiles JM, Evans WJ, Bhasin S, Cella D, Deutz NE, Doehner W, Fearon KC, Ferrucci L, Hellerstein MK, Kalantar-Zadeh K, Lochs H, MacDonald N, Mulligan K, Muscaritoli M, Ponikowski P, Posthauer ME, Rossi FF, Schambelan M, Schols AM, Schuster MW, Anker SD
doi: 10.1016/j.celrep.2016.05.092
Molnar Z, Shearer E, Lowe D, et al
The gap between achieving a healthy lifestyle and managing side effects leaves individuals with difficult choices: limiting or discontinuing GLP-1s altogether or turning to other drugs or supplements that may contain artificial or synthetic ingredients
Its phase 2 data, published in the New England Journal of Medicine in 2023, showed about 24% weight loss at the highest dose over 48 weeks, and later phase 3 results pushed toward 28%
Serious adverse events related to supplements should be reported to the FDA through the MedWatch program, and manufacturers are legally required to report serious adverse events to the FDA
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